Eliminate the Impossible

Some abilities trigger "whenever you sacrifice a Clue". Those abilities trigger whenever you sacrifice a Clue for any reason, not just to activate a Clue's activated ability.

If a creature is already suspected, suspecting it again won't have any effect.

Being suspected isn't a copiable value. If a permanent becomes a copy of a suspected creature, it won't be suspected.

If a suspected creature loses all abilities, it will lose menace and "This creature can't block", but it won't stop being suspected.

Eliminate the Impossible affects only creatures your opponents control at the time it resolves. Creatures they begin to control later in the turn won't get -2/-0 and won't stop being suspected.

You can't sacrifice a Clue to pay multiple costs. For example, you can't sacrifice a Clue token to activate its own ability and also to activate Alquist Proft, Master Sleuth's ability.

Some spells and abilities that investigate may require targets. If each target chosen is an illegal target as that spell or ability tries to resolve, it won't resolve. You won't create any Clue tokens.