Blood Hustler

For example, an ability that triggers when you cast a spell that targets an opponent will trigger at the same time as an ability that triggers whenever you commit a crime. Those abilities can be put on the stack in either order (if you control them both), and they’ll both resolve before the spell that caused them to trigger.

If the target opponent is an illegal target as Blood Hustler’s activated ability tries to resolve, it won’t resolve and none of its effects will happen. You won’t gain life.

A player commits a crime as they cast a spell, activate an ability, or put a triggered ability on the stack that targets at least one opponent, at least one permanent, spell, or ability an opponent controls, and/or at least one card in an opponent’s graveyard.